So, with the intense/rapid development of the low pressure over the southwestern Atlantic, this is what's causing the LES from Lake Lainer? Not sure if that is LES coming from Lake Lainer, but it surely does look like it.
Lake effect snow is unusual over our part of the world because either the low-mid level temperatures aren't cold enough, we have insufficient synoptic-scale forcing (namely, a pressure gradient that's too weak, cyclones and surface highs tend to be stronger to our north), & particularly when contrasted against the Great Lakes, we don't have large enough bodies of water to build up adequate amounts of moisture so that we can generate clouds & snow. For lake effect snow, you want:
1) Adequate synoptic-scale forcing, i.e. a tight pressure gradient (& thus strong winds ) between corresponding areas of low and high pressure
2) At least a 50-80 kilometer wind fetch over a lake or other large body of water
3) 13C (or more) difference between the 850 hPa temperature and lake body temperature. This is nearly equivalent to the adiabatic lapse rate of 10C per km, so this is essentially an indication of instability. The greater the temperature difference between the low-levels (850 hPa in this instance) and the lake, the more instability, and thus a stronger tendency for vertical motion in the low-levels.
4) Low-level inversion height of at least 1 kilometer. Usually, w/ very intense arctic air masses, they're often strongest in the low-levels of the atmosphere (essentially because colder air sinks) and are capped by an inversion layer over top of the cold dome, so when you have a deeper arctic airmass, when the potential does exist for lake effect snow, the depth through which the atmosphere can mix and create low-topped convection is greater the deeper the arctic airmass is and vis versa.
Again, as mentioned the biggest inhibitor most often for us seeing lake effect snow around here is the fact that our low-level temperatures aren't cold enough, however they're liable to be very frigid in the wake of this monstrous low pressure system... Take note 850 temperatures in this GFS forecast are between -13 and -16C for 0z Friday, assuming the lakes aren't frozen and are probably cold (~5C ish temperature wise), this argues that we'll be safely above the 13C cut-off needed between the 850 hPa and lake temperature to potentially generate lake effect snow. Now, we may have some residual moisture spilling over the Appalachians from the Great Lakes so we may be able to get away w/ a wind fetch that's a little less than 50 kilometers, and we should have no issues w/ the inversion height of this intense arctic airmass and getting a pressure gradient between our beast offshore and the cold, Canadian high pressure center building down its wake.
850 hPa temps get even colder for NC later in the GFS run as this low departs, dipping down to about -20C, thus as long as some of our local lakes aren't frozen over given the aforementioned conditions in place and if we can get a little extra moisture from the Great Lakes, I wouldn't be surprised to see some lake effect snow off of Lake Kerr and/or maybe even Lake Jordan.
As recently as January 2014, we had Lake Effect snow in NC, a nice band developed off of Lake Kerr near the NC-VA border on the 22nd and dumped up to an inch or so of snow in portions of Nash, Wilson, & Wayne counties.
Checking the KGSO sounding at the time of this event shows indeed, with lakes that weren't frozen over (~5C or so), the -14C 850 hPa temperatures here (highlighted in yellow) were sufficient to generate lake effect snow in NC