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Coronavirus (Stay on Topic)

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GaWx said:
I'm assuming I had the original strain when I had COVID back in January. Does @Jon or anyone else know if I'd likely be protected from the B.1.1.7 variant for awhile due to antibodies from the original strain? Or would that just protect me from the original strain?
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Snowfan just posted a great study which does show some lingering neutralizing antibodies from the original covid lineage against B.1.1.7 but it also shows this neutralizing antibody activity decays over time. This actually supports vaccination of previously infected individuals.

We’ve seen studies where previously infected people who produce neutralizing antibodies can have 9 months of protection...but the hard part is knowing if you’re one of these people. Simply having a history of covid-19 infection doesn’t mean you produced any neutralizing antibodies at a good enough level to combat a covid-19 reinfection. For instance, in my case, my antibodies weren’t even detected 7mo post infection.

I’d recommend the vaccine of course, but it’s a good question and I think the jury is still out and the answer 110% varies from person to person, viral load, and your own immune system.
 
Snow_chaser said:
Definitely interested in this. Larry, was you pretty weak for awhile after your recovery? I can walk on treadmill at 2.4 mph for 45 minutes and be fine. Today my wife and I put together a gas grill and I thought I was going to die. Absolutely no upper body strength and just no energy
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I didn't start to turn the corner until days 11-12, when my fever finally went away with no Tylenol. I first sat outside on day 14 and did my first half walk at not quite at full exercise speed on day 16. By the end of week 3, I had done a 75% walk and any lingering cough or fatigue had largely ended, but I had still had a little bit of the lingering funny taste and my sense of smell was still weak. During week 4 I did my first full walk and it was at normal speed. However, smell still wasn't normal. So, all in all, other than smell, it took me about a month to get back to normal. What may have helped me recover was the regular walking I've done for 25+ years although the fever/tiredness/terrible taste/lack of appetite seemed endless when I had it compared to almost all other infections I've had as an adult.
 
GaWx said:
I didn't start to turn the corner until days 11-12, when my fever finally went away with no Tylenol. I first sat outside on day 14 and did my first half walk at not quite at full exercise speed on day 16. By the end of week 3, I had done a 75% walk and any lingering cough or fatigue had largely ended, but I had still had a little bit of the lingering funny taste and my sense of smell was still weak. During week 4 I did my first full walk and it was at normal speed. However, smell still wasn't normal. So, all in all, other than smell, it took me about a month to get back to normal. What may have helped me recover was the regular walking I've done for 25+ years although the fever/tiredness/terrible taste/lack of appetite seemed endless when I had it compared to almost all other infections I've had as an adult.
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Thanks for sharing. I’m in a situation that due to a back injury I was granted total disability 4 yrs ago and have basically sat around the house and done nothing but gain weight and get in poorer health. I give God all the credit for bringing me through the actual sickness part with it being no worse than it was. With high BP, being obese, probably about 335 at 6’3, and being vitamin D3 deficiency this could have been a very different outcome. I got the regeneron on day 10 so not sure exactly how much it helped, they say get it within 10 days of symptom onset. I easily lost 25 lbs during the actual sickness and now I’m in the process of trying to build my strength back up and take better care of myself. I’m eating better and walking and only drinking water now. I am now down to about 292 lbs. I’ve not got my BMI down to stage 2 of obesity instead of stage 3 morbid obesity. Waiting on my lab results to see where my latest numbers are overall and see if the antibodies show up on my bloodwork
 
Jon, can you explain the way that regeneron works? The ER dr told me it’s supposed to keep the virus from attacking or invading other cells after the infusion? If that’s true and if it works, I wonder if there’s any studies been done yet to see if that would potentially reduce long term issues from the virus? I know you have the initial infection that could cause issues long term but maybe if the virus doesn’t invade other cells then there may be some sort of protection from other issues?
 
I thought I heard yesterday that Phizer vaccine was 80% effective or greater after just the first dose, per their study. Anybody else heard this?
 
Tarheel1 said:
I thought I heard yesterday that Phizer vaccine was 80% effective or greater after just the first dose, per their study. Anybody else heard this?
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Thought I’d seen that to. Also read somewhere that people that have recovered from Covid the antibodies is like getting the first vaccine? If so, wonder why they can’t give Covid survivors just one shot and it be good
 
Snow_chaser said:
Jon, can you explain the way that regeneron works? The ER dr told me it’s supposed to keep the virus from attacking or invading other cells after the infusion? If that’s true and if it works, I wonder if there’s any studies been done yet to see if that would potentially reduce long term issues from the virus? I know you have the initial infection that could cause issues long term but maybe if the virus doesn’t invade other cells then there may be some sort of protection from other issues?
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The news always called it an “antibody cocktail” and that’s pretty much what it is. It has two different monoclonal neutralizing antibodies in it. Monoclonal antibodies (mAb) are relatively new form of medicine over the last decade or so, used in a lot of illnesses to block either receptors or ligands.

If a mAb blocks a receptor on a cell, it prevents the ligand from attaching to the cell.

If a mAb attaches or binds to a ligand, it prevents the ligand from connecting to a receptor and attaching to a cell.

For regeneron specifically, the mechanism is as follows:
“Casirivimab and imdevimab bind to non-overlapping epitopes of the spike protein receptor binding domain (RBD) of SARS-CoV-2”

So in this case the mAb’s bind to the spike protein (or ligand) on free floating virus cells in the blood. This prevents them from attaching to the ACE2 receptors and doing damage.

To answer your question: by the time you get regeneron, it’s likely the virus has already been everywhere blood goes (aka everywhere) — we know Covid even crosses the blood brain barrier into the brain.

However, it does lower viral load and frees floating virus in the blood from binding and stops/slows the amount of damage the virus is doing or WOULD do. So it definitely would stop further lung damage.

To expand on why it’s likely not going to help with long COVID...mAbs are just mAbs, and unless they’re binding to the spike protein, they don’t have a “job” and are just free floating in blood until they are waisted through urine over time and leave your system. So they aren’t helping anything unless you have virus in your blood. This is why they tell you to wait to get the vaccine since the vaccine will produce fake spike proteins, they don’t want regeneron binding to them and screwing up your immune response.

Sorry I rambled hopefully I answered your question.
 
Snow_chaser said:
Thought I’d seen that to. Also read somewhere that people that have recovered from Covid the antibodies is like getting the first vaccine? If so, wonder why they can’t give Covid survivors just one shot and it be good
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That’s the thought being floated around right now. I’m only speculating, but I think eventually they’ll say if you’ve had prior infection within the last X months, only one dose of the mRNA vaccines is required. I’m sure they’re doing some trials on that now.

I’d like to see data on immune response of:
COVID + dose 1 + dose 2
COVID + dose 1
Dose 1 + dose 2

I wonder if the first group is hitting that 95% number. It would make sense, it’s like getting 2 strong booster shots.
 
Jon said:
That’s the thought being floated around right now. I’m only speculating, but I think eventually they’ll say if you’ve had prior infection within the last X months, only one dose of the mRNA vaccines is required. I’m sure they’re doing some trials on that now.

I’d like to see data on immune response of:
COVID + dose 1 + dose 2
COVID + dose 1
Dose 1 + dose 2

I wonder if the first group is hitting that 95% number. It would make sense, it’s like getting 2 strong booster shots.
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I know everyone is different, but I wonder if that’s why I’ve read about some Covid survivors saying their first shot reaction was a lot like some people’s second shot. The actual virus was like the first shot primer.
 
Snow_chaser said:
I know everyone is different, but I wonder if that’s why I’ve read about some Covid survivors saying their first shot reaction was a lot like some people’s second shot. The actual virus was like the first shot primer.
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I have seen the measured response i.e. antibodies etc has been outstanding after 1 dose for those that have already had COVID. Better than the 2nd dose for those who have not had the virus.
 
I got my first moderna shot yesterday. Other than the Kiss song playing backwards in my head, and my new Hobbit-like feet, everything seems just fine.

But seriously, I do have a bit of nausea this morning but otherwise no big deal. I’m not looking forward to the second dose of Moderna.
 
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